Glucocorticoids in health and disease with special reference to glucocorticoid receptor signalling pathways and molecular networking

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dc.contributor.authorKharwanlang, Banteiskhem
dc.contributor.authorSharma, Ramesh
dc.date.accessioned2014-01-27T07:41:58Z
dc.date.available2014-01-27T07:41:58Z
dc.date.issued2014-01-27
dc.description.abstractGlucocorticoids have a diverse role in physiological and pathological conditions, making them a class of potent drugs in clinical use ranging from organ transplantation, arthritis, asthma, and chronic obstructive pulmonary diseases (COPD) to oncological problems. The use of glucocorticoids in clinical practices, however, is associated with many side effects and steroid resistance in certain diseases. Understanding the underlying mechanism of glucocorticoid action is an ultimate concern in overcoming these complications. Several studies have pointed the role of glucocorticoid receptor interaction with many other signalling pathways in these situations. Designing of drugs that could modulate these interactions, while maintaining glucocorticoid receptor molecular network in a homeostatic balance, is a challenge in glucocorticoids pharmacology. Some prospective molecules like theophylline and compound A, are reported to have such effect.en_US
dc.document.departmentCentral Libraryen_US
dc.document.yearofpublication2013en_US
dc.identifier.urihttps://dspace.nehu.ac.in/handle/1/11403
dc.journal.pagerange31-40en_US
dc.language.isoenen_US
dc.subjectGlucocorticoids associated problemsen_US
dc.subjectglucocorticoid receptorsen_US
dc.subjectGlucocorticoid receptor signallingen_US
dc.subjectMolecular networken_US
dc.submitter.addressNorth-Eastern Hill University, Shillong 793022 Meghalaya, Indiaen_US
dc.titleGlucocorticoids in health and disease with special reference to glucocorticoid receptor signalling pathways and molecular networkingen_US
dc.typeArticleen_US
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