Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice

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dc.contributor.authorDkhar, Preeticia
dc.contributor.authorSharma, Ramesh
dc.date.accessioned2014-01-27T07:55:59Z
dc.date.available2014-01-27T07:55:59Z
dc.date.issued2014-01-27
dc.description.abstractOxidative stress is an important factor in causing aging and age-related diseases. It is caused by an imbalance between oxidants such as reactive oxygen species (ROS) and antioxidants. Protein oxidation elicited by free radicals may cause protein function disruptions. Protein carbonyl-ation, an irreversible process resulting in loss of function of the modified proteins, is a widely used marker for oxidative stress. In the present study, we have evaluated the levels of protein carbonyls, ROS, and catalase in the cerebral hemi-spheres of young and aged mice. When aged mice were subjected to a dietary restriction (DR) regimen (alternate days feeding) of 3 months, a significant reduction in the endogenous levels of protein carbonylation as well as ROS and elevation of catalase was observed in their cerebral hemispheres. The present study, thus, demonstrated the antioxidative effects of late-onset DR regimen in the cere-bral hemispheres of aged mice which may act as a powerful modulator of age-related neurodegenerative diseasesen_US
dc.document.departmentCentral Libraryen_US
dc.document.placeofpublicationNew Yorken_US
dc.document.publisherSpringeren_US
dc.document.sourceCellular and molecular neurobiologyen_US
dc.document.sourceThe final publication is available at link.springer.comen_US
dc.document.yearofpublication2013en_US
dc.identifier.issn0272-4340
dc.identifier.urihttps://dspace.nehu.ac.in/handle/1/11404
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs10571-013-0015-8
dc.journal.pagerange1-9en_US
dc.journal.volume33en_US
dc.language.isoenen_US
dc.subjectAgingen_US
dc.subjectProteinen_US
dc.subjectCarbonylsen_US
dc.subjectDietary restrictionen_US
dc.subjectCatalaseen_US
dc.subjectReactive oxygenen_US
dc.subjectSpeciesen_US
dc.subjectCerebral hemispheresen_US
dc.submitter.addressNorth-Eastern Hill University, Shillong 793022 Meghalaya, Indiaen_US
dc.titleLate-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged miceen_US
dc.typeArticleen_US
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Ramesh Sharma