Browsing by Author "Sharma, Ramesh"
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- ItemAge- and tissue- specific regulation of chicken inorganic pyrophosphatase(2011-12-09) Syiem, Don Kupar; Sharma, Ramesh
- ItemAge-dependent activation of glucocorticoid receptors in the cerebral hemisphere of male rats(2012-03-27) Sharma, Ramesh; Timiras, Paola S
- ItemAge-dependent decrease in renal glucocorticoid receptor function is reversed by dietary restriction in mice(2011-06-02) Sharma, Ramesh; Dutta, Debipreeta
- ItemAge-dependent dietary regulation of glucocorticoid receptors in the liver of mice(2011-08-03) Dutta, Debipreeta; Sharma, Ramesh
- ItemAge-dependent dietary regulation of glucocorticoid receptors in the liver of mice(2010-12-08T05:49:14Z) Dutta, Depipreeta; Sharma, Ramesh
- ItemAge-dependent dietary regulation of glucocorticoid receptors in the liver of mice(2010-06-11T15:50:27Z) Dutta, Debipreeta; Sharma, Ramesh
- ItemAge-dependent increased expression and activity of inorganic pyrophosphatase in the liver of male mice and its further enhancement with short- and long-term dietary restriction(2013-11-25) Kharbhih, Wanaiborlang Jala; Sharma, RameshIntracellular orthophosphate and inor- ganic pyrophosphate (PPi) are by-products of multiple biosynthetic reactions. PPi hydrolysis by soluble inorganic pyrophosphatase (iPPase) has been consid- ered as an important homeostatic mechanism. We investigated the expression and activities (U/mg protein) of iPPase in the liver of young and old mice subjected to short- and long-term dietary restriction. The expression level of iPPase was ascertained by the Western blot analysis using anti-iPPase and differen- tial polymerase chain reaction using iPPase specific primer. Older mice showed a significant increase in the expression and activity of iPPase as compared to younger ones. Short-term fasting of 24 h increased the expression and activity of iPPase in the liver of both young and old mice which were reversed upon 24 h of re-feeding them. However, both young and old mice on long-term dietary restriction showed a cumulative increase in the expression and activity of iPPase when compared with their age-matched controls. This might be due to accumulative adaptation to refill energy deficiency of long-term dietary restricted mice for ATP generation via oxidative phosphorylation, where fatty acid activation could be driven by elevated iPPase.
- ItemAge-dependent regulation of aspartate aminotransferase isoemzymes by hydrocortisone in the brain of male rats(2011-11-28) Sharma, Ramesh; Patnaik, S K
- ItemAge-dependent regulation of glucocorticoid receptors in the liver of male rats(2011-08-04) Sharma, Ramesh; Timiras, Paola S
- ItemAge-specific development of malate-aspartate shuttle in the liver and kidney of mice(2011-06-02) Sharma, Ramesh; Dey, Santa; Verma, Rakesh
- ItemAging of the Endocrine System(Elsevier (2020), 2019) Kharwanlang, Banteiskhem; Sharma, Ramesh
- ItemAlloxan diabetes regulates adenosine deaminase activity in mice(2011-11-25) Sharma, L Shanjukumar; Sharma, Ramesh
- ItemAmelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid(2013-01-20) Dkhar, Preeticia; Sharma, Ramesh
- ItemAmelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid(2011-09-26) Sharma, Ramesh; Dkhar, Preeticia
- ItemArginase I regulation by dexamethasone in the liver of aging mouse(Springer (2017), 2017) Majaw, Teikur; Sharma, Ramesh
- ItemAttenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin(2013-11-25) Dkhar, Preeticia; Sharma, RameshProtein carbonyls are formed as a consequence of the oxidative modification of proteins by reactive oxy- gen species and are commonly used as a marker of protein oxidation in cells and tissues. Melatonin has free radical scavenging ability besides its classical role as a hormonal signaling agent. Curcumin, a phytochemical, has a wide variety of biological actions including anti-inflammatory and antioxidative. In the present study, the effects of melatonin and curcumin on age-related carbonyl content of liver in mice were investigated. Young (1 month) and aged (18 month) were administered with melatonin (10 mg/kg body weight) and curcumin (90 mg/kg body weight) in dimethyl sulfoxide intraperitoneally. Livers were excised from each experimental group and processed. The level of protein carbonylation was assessed spectrophotometrically and further confirmed by Western blotting analysis. Protein carbonyls of liver have been found to be significantly higher in 18-month-old mice as compared to 1-month-old mice. The carbonyl content in 1- and 18-month-old mice decreases significantly upon administrations of melatonin and curcumin. This study thus suggests that the formation of protein carbonyls in the liver of the aging mice can be prevented by the antioxidative effects of melatonin and curcumin, which may provide health benefits in aging animals.
- ItemBeneficial biochemical outcomes of late-onset dietary restriction in rodents(2011-08-03) Goto, Sataro; Takahashi, Ryoya; Radak, Zsolt; Sharma, Ramesh
- ItemBeneficial effects of dietary restriction in aging brain(Elsevier B.V., 2019) Hynniewta Hadem, Ibanylla Kynjai; Majaw, Teikur; Kharbuli, Babiangshisha; Sharma, Ramesh
- ItemBeneficial effects of nutraceuticals in healthy brain aging(2020) Dkhar, Preeticia; Sharma, Ramesh
- ItemBiological basis of aging : Theories and explanations(CRC Press (1994), 2017) Sharma, Ramesh; Dkhar, Preeticia