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Browsing by Author "Dkhar, Preeticia"

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    Amelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid
    (2013-01-20) Dkhar, Preeticia; Sharma, Ramesh
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    Amelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid
    (2011-09-26) Sharma, Ramesh; Dkhar, Preeticia
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    Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin
    (2013-11-25) Dkhar, Preeticia; Sharma, Ramesh
    Protein carbonyls are formed as a consequence of the oxidative modification of proteins by reactive oxy- gen species and are commonly used as a marker of protein oxidation in cells and tissues. Melatonin has free radical scavenging ability besides its classical role as a hormonal signaling agent. Curcumin, a phytochemical, has a wide variety of biological actions including anti-inflammatory and antioxidative. In the present study, the effects of melatonin and curcumin on age-related carbonyl content of liver in mice were investigated. Young (1 month) and aged (18 month) were administered with melatonin (10 mg/kg body weight) and curcumin (90 mg/kg body weight) in dimethyl sulfoxide intraperitoneally. Livers were excised from each experimental group and processed. The level of protein carbonylation was assessed spectrophotometrically and further confirmed by Western blotting analysis. Protein carbonyls of liver have been found to be significantly higher in 18-month-old mice as compared to 1-month-old mice. The carbonyl content in 1- and 18-month-old mice decreases significantly upon administrations of melatonin and curcumin. This study thus suggests that the formation of protein carbonyls in the liver of the aging mice can be prevented by the antioxidative effects of melatonin and curcumin, which may provide health benefits in aging animals.
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    Beneficial effects of nutraceuticals in healthy brain aging
    (2020) Dkhar, Preeticia; Sharma, Ramesh
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    Biological basis of aging : Theories and explanations
    (CRC Press (1994), 2017) Sharma, Ramesh; Dkhar, Preeticia
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    Carbonyl modification of proteins as a function of age in mice: Its modulation by dietary restriction and hormonal treatments
    (2019) Dkhar, Preeticia; Sharma, R. (Supervisor)
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    Effect of dimethylsulphoxide and curcumin on protein carbonyls and reactive oxygen species of cerebral hemisphere of mice as a function of age
    (2011-08-03) Sharma, Ramesh; Dkhar, Preeticia
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    Interventions for healthy aging
    (2017) Sharma, Ramesh; Dkhar, Preeticia
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    Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice
    (2014-01-27) Dkhar, Preeticia; Sharma, Ramesh
    Oxidative stress is an important factor in causing aging and age-related diseases. It is caused by an imbalance between oxidants such as reactive oxygen species (ROS) and antioxidants. Protein oxidation elicited by free radicals may cause protein function disruptions. Protein carbonyl-ation, an irreversible process resulting in loss of function of the modified proteins, is a widely used marker for oxidative stress. In the present study, we have evaluated the levels of protein carbonyls, ROS, and catalase in the cerebral hemi-spheres of young and aged mice. When aged mice were subjected to a dietary restriction (DR) regimen (alternate days feeding) of 3 months, a significant reduction in the endogenous levels of protein carbonylation as well as ROS and elevation of catalase was observed in their cerebral hemispheres. The present study, thus, demonstrated the antioxidative effects of late-onset DR regimen in the cere-bral hemispheres of aged mice which may act as a powerful modulator of age-related neurodegenerative diseases
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    Protein carbonylation, a marker of oxidative stress, during aging and its modulation by dietary restriction
    (McGraw Hill Education (2014), 2017) Sharma, Ramesh; Dkhar, Preeticia

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